Information of K252b BioChemica

Product name:K252b BioChemica
CAS:99570-78-2
Molecular formula:C26H19N3O5
Molecular weight:453.45 g/mol
Description of K252b BioChemica:
K252b is a microbial alkaloid acting as a protein kinase inhibitor belongig to the family of Staurosporines, chemicaly belonging to the indolcarbazoles. These inhibitors competitively bind to the ATP-binding site in the kinase domain. K252b is non cell-permeable and inhibits ecto-kinases, such as protein kinase C (IC50 38.3 nM), cAMP-dependent protein kinase, cGMP-dependent protein kinase and myosin light-chain kinase. It selectively potentiates the activation of the nerve growth factor receptors, TrkA, by neurotrophins, which play an important role in the maintenance of neurons. K252b arrests normal human skin fibroblasts approximately 4 hours after the transition from G0 to G1 in the cell cycle, but not transformed cells. In the brain, K252b seems to be a selective inhibitor of the NGF action, but without showing cytotoxic activity or loss of cells.
Assay (TLC):min. 97 % 
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