What is Leptomycin B

Product name:Leptomycin B
CAS:87081-35-4
Molecular formula: C33H48O6
Molecular weight:540.73 g/mol
Description of Leptomycin B:
Synonyms:Elactocin, Mantuamycin
Solubility:Leptomycin B is soluble in ethanol, methanol
Appearance: Clear colorless liquid.
Applications:Leptomycin B (LPB) was originally discovered as a potent anti-fungal antibiotic from Streptomyces sp. However, recent data (2003)  showed that Leptomycin causes G1 cell cycle arrest in mammalian cells and is a potent anti-tumor agent against murine experimental tumors.
Leptomycin B is a potent and specific nuclear export inhibitor. Leptomycin B alkylates and inhibits CRM1 (chromosomal region maintenance)/exportin 1, a protein required for nuclear export of proteins containing a nuclear export sequence (NES). In addition to antifungal and antibacterial activities, Leptomycin B blocks the cell cycle and is a potent anti-tumor agent. At low nM concentrations, Leptomycin B blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF-κB/IκB, and it stabilizes the expression of p53. Leptomycin B also inhibits the export and translation of many RNAs, including COX-2 and c-Fos mRNAs, by inhibiting export of ribonucleoproteins.
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