α1-Antitrypsin, Human for Sale

Product name:α1-Antitrypsin, Human
CAS:9041-92-3
Description of α1-Antitrypsin, Human:
Synonym :α1-Proteinase Inhibitor
Origin :from human serum
Additional product description:lyophilized from 20 mM sodium bicarbonate. May contain traces of buffer salts.
Assay (SDS-PAGE):min. 95 %
Alpha 1-Antitrypsin or α1-antitrypsin (A1AT) is a protease inhibitor belonging to the serpin superfamily. It is generally known as serum trypsin inhibitor. Alpha 1-antitrypsin is also referred to as alpha-1 proteinase inhibitor (A1PI) because it inhibits a wide variety of proteases. It protects tissues from enzymes of inflammatory cells, especially neutrophil elastase, and has a reference range in blood of 1.5 - 3.5 gram/liter (in US the reference range is generally expressed as mg/dL or micromoles), but the concentration can rise manyfold upon acute inflammation. In its absence, neutrophil elastase is free to break down elastin, which contributes to the elasticity of the lungs, resulting in respiratory complications such as emphysema, or COPD (chronic obstructive pulmonary disease) in adults and cirrhosis in adults or children.
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